摘要
目的通过应用咪唑安定和苯巴比妥钠作为术前用药,观察2种不同药物对手术患者围术期的镇静、遗忘作用的影响。方法选择ASA I～II级择期妇科开腹手术患者90例,随机分为3组,每组30例,A组咪唑安定0.1 mg/kg,B组咪唑安定0.05 mg/kg,C组组苯巴比妥钠2 mg/kg。观察用药后血流动力学变化、牵拉反应、恶心呕吐情况,在注药后5,10,20,30,60 min,参照Ramsy改良分级法,进行镇静程度分级。结果清醒镇静作用A组与B组明显高于C组(P<0.05),对麻醉、手术过程的遗忘作用A组与B组明显多于C组(P<0.05)。结论在硬膜外阻滞麻醉前30 min肌注咪唑安定0.05 mg/kg较为适宜,既有利麻醉操作,又起到了良好的镇静及顺位遗忘作用,同时也是安全的。
Objective To observe the sedation and amnesia effects of midazolam and phenobarbital sodium applied as preoperative medication to perioperative patients.Methods Ninety gynecological abdominal surgery patients,ASA I-II,were randomly divided into 3 groups,each group 30 cases.In group A,midazolam 0.1mg/kg was used as preoperative medication.In group B,midazolam 0.05mg/kg was used as preoperative medication.And in group C,phenobarbital 2mg/kg was used as preoperative medication.Hemodynamic changes,traction reaction,nausea and vomiting situation were observed after treatment.5,10,20,30 and 60 minutes after injection,classification of sedation level was conducted according to the improved Ramsy classification method.Results Conscious sedation in group A and group B was significantly higher than group C（P0.05）;the amnesia effects of anesthesia and surgical procedures in group A and group B was significantly higher than group C（P0.05）.Conclusion Injecting 0.05mg/kg midazolam intramuscular 30 minutes before epidural anesthesia is appropriate and safe,which had both favorable effects for operation and anesthetic sedation and amnesia.
出处
《职业卫生与病伤》
2011年第5期307-308,共2页
Occupational Health and Damage
关键词
咪唑安定
苯巴比妥钠
镇静作用
遗忘作用
midazolam
phenobarbital sodium
sedation effect
amnesia effect
