摘要
目的:探讨改良电痉挛治疗(MECT)对抑郁症治疗的疗效及安全性。方法:将100例首发抑郁症患者随机分为两组,分为单用氟西汀(下称对照组)组和氟西汀与电痉挛治疗联合应用组(下称联用组),观察时间为8周。于基线及治疗1、2、4、6、8周末,采用汉密尔顿抑郁量表(HAMD)评定疗效,采用治疗中需处理的不良反应症状量表(TESS)和心电图的改变评价治疗的安全性。最终纳入分析联用组和对照组各48例。结果:联用组自治疗第1周末、对照组自治疗第4周末,HAMD焦虑/躯体化、认识障碍、阻滞、绝望感4个因子分和总分显著下降,与基线的差异具有统计学意义(P<0.05或P<0.01);自治疗第6周末始两组患者的HAMD全部7个因子分相比无统计学差异。8周观察中未发现二者对心电图有明显影响。结论:改良电痉挛治疗对首发抑郁症的治疗有良好的疗效,而且起效迅速,安全性较好,对记忆功能早期有一定影响,一般在1个月左右恢复。
Objective：To discuss therapeutic efficacy and safety of MECT in first - episode depressive patients. Methods： We divided 100 depressive patients into combined treated group and contrasted group randomly , then observing 8 weeks. To evaluate therapeutic efficacy with HAMD at baseline and lth , 2 th, 4 th , 6th, 8th weekend. To evaluate therapeutic safety with TESS and electrocardiogram changes. Ultimately we analyze 48 patients in each group respectively. Result： There are four kinds of factor （HAMD） anxiety/ somatization, awarene~ barriers, block, hopelessness）score and total score have significant decrease since the first weekend in two groups and since the 4th weekend in contrasted group . There are significant difference contrast with baseline （P（ 0.05 or P 〈 0.01）. There are no significant difference in 7 kinds of factor score of HAMD since 6th weekend in two groups . There are no significant effect to ECG in 8 weeks. Conclusion： In our investigation , MECT shows favorable therapeutic efficacy and rapid exert effect and nicer safety as well as.
出处
《内蒙古医学杂志》
2011年第11期1302-1305,共4页
Inner Mongolia Medical Journal
关键词
改良电痉挛治疗
氟西汀
抑郁症
Modified Electroconvulsive therapy
Fluoxeting
Depression
