摘要
新西兰免78只分成8组。试验组、M组和对照组分别静滴去甲肾上腺素(NE)1毫克/公斤、美索克新明或生理盐水。其余5组在NE之前分别给予酚妥拉明(R组)、心得安(P组)、美多心安(MP组)、育亨宾(Y组)以及(口派)唑嗪(PR组)。以半定量方法分析心肌病理损害程度,并测定心肌中糖酵解中间产物11项以及能量代谢产物。结果发现NE组心肌损害显著(P<0.01);P组、MP组、Y组和M组心肌损害类似于NE组;R组和PR组则较NE组减轻(P<0.01)。NE组和MP组心肌尚有明显的代谢障碍,而R组则较接近正常。提示NE所致心肌损害中α受体,尤其α_1受体起了主要作用。作者等对其发生机理进行讨论,并提出新的假设。
Seventy eight New Zealand rabbits were divided into 8 groups. NE, M, and control group were given norepinephrine (1mg/kg), methoxamine or saline, respectively. The other 5 groups were given regitine (R group), propranolol (P group), metaprolol (MP group), yohimbine (Y group) and prazosine (PR group) respectively before NE infusion.Myocardial injury was estimated with a semi-quantitative histological scoring system, and 11 intermediate metabolites in glycolysis and ATP, ADP, AMP, CP in myocardium were measured. Results showed that myocardial injury was observed in NE group (P<0.01),as well as in P, MP, Y and M groups; group R and PR tended to have less myocardial injury in comparison with NE group. Metabolic dysfunction was found in NE and MP group, while group R showed a nearly normal glycolysis and energy metabolizm. Conclusion: α-adrenoceptor, especially α_1 receptor, plays the key role in development of NE-induced myocardial injury. As for its mechanism we put forward a new hypothesis.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1990年第5期313-316,共4页
Chinese Journal of Pathophysiology
基金
国家自然科学基金
关键词
心肌损害
受体
儿茶酚胺
Norepinephrine
Receptors adrenergic alpha
Receptors, adrenergic beta
Catecholamines
Glycolysis
