摘要
本文报告了用放射免疫法测定家兔血浆中TXB_2及6-Keto-PGF_(1α)的结果。并对外周耳缘静脉及颈内静脉不同部位采血测定结果进行了对比。结果表明,结扎动脉30分钟后造成腑缺血,血浆TXB_2含量明显高于对照组(P<0.01);由颈内静脉采血组测得值,明显高于外用耳缘静脉采血组(P<0.01)。脑缺血组,血浆6-Keto-PGF_(1α)含量,明显低于对照组(P<0.01);由颈内静脉采血组其含量明显低于外周耳缘静脉采血组(P<0.01)。由于闭塞动物颈部大动脉所致的脑缺血,血浆TXB_2/6-Keto-PGF_(1α)比值明显高于对照组。
Acute ligation of the common carotid artery on one side internal carotid artery on opposite side resulted in experimental cerebral ischemia in rabbit. Measurement of thromboxane B_2 (TXB_2) and 6-Keto-prostaglandin F_(1α)(6-Keto-PGF_(1α))in rabbit plasma were done by radioimmunoassay. Blood samples were collected from the peripheral vein and internal carotid vein. The results were as follows:1. The concentration of TXB_2 in rabbit cerebral ischemia (ligation after 30 min.) was significantly (P<0.01) higher than that in health. 2. The concentration of TXB_2 in internal carotid venous blood were significantly(P<0.01) higher than that in peripheral venous blood. 3. The concentration of 6-Keto-PGF_(1α) in rabbit cerebral ischemia was sigdnificantly(P<0.01) lower than that in health. 4. The concentration of 6-Keto-PGF_(1α) in internal carotid vein was significantly (P<0.01) lower than that in peripheral venous blood. The animal with cocclusive lesions of major cerebral arteries exhibited higher TXB_2/ 6-Keto-PGF_(1α) ratios than the health both in internal carotid venous plasma and in peripheral venous plasma.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1990年第4期211-214,共4页
Chinese Journal of Pathophysiology
关键词
脑缺血
血栓素B2
前列腺素X类
Thromboxane B_2 (TXB_2)
Prostaglandins X
Cerebral ischemia
