摘要
通过复制大鼠甲状腺功能低下和亢进的动物模型,以放射免疫测定的方法,观察了此两种情况下下丘脑、纹状体、大脑皮质等脑区及整个垂体亮-脑啡肽样免疫活性物质(Ir-LEK)含量的改变。结果表明,此两种情况下,脑及垂体Ir-LEK含量都发生了明显的变化。甲低组下丘腩、大脑皮质及垂体Ir-LEK较正常对照组明显升高,相反,甲亢组下丘、大脑皮质较正常显著减少。
In presnt experiment, animal models for hyperthyroidism and hypothyroidism were made, and using radioimmunoassay, the immunoeactive leucine-enkephalin (Ir-LEK) levels of such discrete brain areas as hypothalamus, striatum, cerebral cortex(frontal lobe) and whole pituitary were determined in different groups. The results obtained indicated that both hyperthyroidism and hypothyroidism induced significant changes of concentration in CNS Ir-LEK. It was found in hypothyroid group that concentration of Ir-LEK in hypothalamus, cerebral cortex and pituitary increased significantly against the control (P<0.05 & 0.001), meanwile, a trend of enhancement could be seen in other region also. On the contrary, in hyperthyroid group, levels of Ir-LEK hypothalamus and cerebral cortex were decreased(P<0.05 & 0.02), and those in striatum and pituitary got lower too, but not significantly in statistics. These results suggested that thyroidhormone might be involved in the regulation mechanism of CNS LEK and that it will be important and helpful for demonstrating thoroughly the disorders of patients with hyper-& hypothyroidism in clinics.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1990年第3期176-179,共4页
Chinese Journal of Pathophysiology
关键词
甲亢
甲减
脑啡肽
亮氨酸
脑
Hyperthyroidism
Hypothyroidism
Enkephalin, leucine
