期刊文献+

HBME-1、CK19、Galectin-3、34βE12在甲状腺微小乳头状癌中的表达

暂未订购
导出
摘要 目的探讨甲状腺微小乳头状癌中HBME-1、CKl9、Galeetin-3、34BE12的表达及意义。方法采用免疫组化sP法检测58例甲状腺微小乳头状癌、30例结节性甲状腺肿,26例甲状腺乳头状增生中的表达。结果HBME-1、CKl9、Galectin-3、34BE12在甲状腺微小乳头状癌和良陛病变(结节性甲状腺肿、甲状腺乳头状增生)中的阳性表达率的差异有十分显著的统计学意义(P〈0.01),MBME-1敏感性、特异性、准确性分别87.9%、94.6%、91.2%,CK19敏感性、特异性、准确性分别为100%、89.2%、95.6%。Galectin-3敏感性、特异性、准确性分别为96.5%、87.5%、92.1%,34BE12敏感性、特异性、准确性分别为89.6%、96.4%、92.9%。结论HBME-1、CK19、Galectin-3、34BE12联合检测将进一步提高甲状腺微小乳头状癌的准确性。
出处 《中国中医药咨讯》 2012年第1期5-6,共2页
  • 相关文献

参考文献8

  • 1Beesley MF, Mclaren KM. Cytokeratin 19 and galectin-3 immunohistochemistry in the differential diagnosis of solitarythyroid nodules [ J ]. Histopathology, 2002, 41:236-243.
  • 2Mauro P, Jaime R, Pompa R D, et al. Galectin-3 and HBME-1 expression in well-differentiated thyroid tumors with follicular architecture of uncertain malignant potential [J]. Modem Pathology, 2005, 18: 541-546.
  • 3PIERSANTI M,EZZAT S,ASA SL.Controversies inpapillary microcarci-noma thyroid[J].Endocr Pathol,2003,14:183.
  • 4de Matos P S, Ferreira A P, de Oliverira Facuri F, et al. Usefulness of HBME-1 ,cytokeratin 19 and galectin-3 immunostaining in the diagnosis of thyroid malignancy[J]. Histopathology,2005,47(4) : 391 - 401.
  • 5Nasser, SM, Pitman,MB, Pilch, BZ, et al. Fine-needle aspiration biopsy ofpapillary thyroid carcinoma: diagnostic utility of cytokeratinl9 immunastaining[J].Cancer, 2000, 90(5): 307-311.
  • 6Rossi ED, Raffaelli M, Mule A, et al. Simultaneous immunohistochemical expression of HBME-1 and galectin-3 differentiates papillary carcinomas from hyperfunctioning lesions of the thyroid[J]. Histopathology,2006, 48(7): 795- 800.
  • 7Kawachi K, Matsushita Y, Yonezawa S,et al. Galectin-3 expression in various thyroid neoplasms and its possible role inmetastasis formation[J]. Hum Patho,12000, 31:428-433.
  • 8Liberman E,Weidner N. Papillary and follicular neoplasms of the thyroid gland: Differential immunohistochemical staining with high- molecular-weightkeratin and involucrin[J].Appl Immunoshitochem Mol-Morpho,12000, 8(1): 42-48.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部