摘要
用65只日本兔喂高脂饲料,观察山莨菪碱对动脉粥样硬化形成的作用及其有关检测指标的影响。结果表明,山莨菪碱组主动脉内膜粥样硬化斑块面积、胆固醇含量、内膜通透性及血液TC、LDL-C、TG、LPO、TXA_2、5-HT、Pt聚集力,血液流变学等,均显著降低;PGI_2及SOD增高;组织光镜及电镜改变减轻。说明山茛菪碱对动脉粥样硬化的形成有显著抑制作用。
We investigated if the drug anisodamine may effect on the formation of atherosclerosis and on the parameters tested. Sixty five rabbits were fed high-cholesterol diet. The results showed that the size of atherosclerotic plaques, cholesterol content, permeability of aortic intima were reduced, and TC, LDL-C, TG, LPO, TXA_2, 5-HT, platelet aggregation, blood viscosity were also significantly decreased, PGI_2 and SOD increased. Under the optic-microscope and electro-microscope, an amelioration of pathological changes occurred. All the above results suggest that the anisodamine might inhibit the development of atherosclerosis in rabbits.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1990年第2期104-107,共4页
Chinese Journal of Pathophysiology
关键词
山莨菪碱
动脉粥样硬化
抑制
Atherosclerosis
Lipid peroxides
Superoxide dismutase
Thromboxane A_2
Prostaglandins I_2
