摘要
本实验系通过对子宫亮氨酸脑啡肽(L-ENK)含量的测定,性激素对它的影响,它在子宫内的定位以及在阻断阿片受体后雌激素对子宫环核苷酸作用的变化等,来对L-ENK在子宫生理方面所起的作用初步作一探讨。发现:人和大鼠子宫含有L-ENK样物,含量与体内雌激素水平呈正相关;L-ENK定位于人及大鼠子宫内膜的间质细胞内;阿片受体阻断剂纳洛酮(NAL)能改变雌激索对子宫环核苷酸的调节作用。结果表明:L-ENK可能在子宫的生理活动中起重要的作用。
By means of radioimmunoassay, leucine-enkephalin (L-ENK) in the uteri of women and rats was studied and its responses to ovarian steroids were observed. The histological localization of L-ENK and the influence of naloxone (NAL) on estrogen regulation of the rat uterus in terms of cAMP and eGMP determination were also studied. Results of the study demonstrated that presence of L-ENK like substance in the uteri of women and rats, and the concentrations varied in the various phases of the sexual cycle. indicating a positive correlation with levels of estrogen in the body. L-ENK was found localized in the interstetial cells of the human endometrium, and in the rat uterus. Effect of extrogen on nucleotide was influenced by NAL. The findings suggested that L-ENK may play an important role on physiologic function of utetus.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1990年第2期87-90,共4页
Chinese Journal of Pathophysiology
关键词
子宫
亮氨酸
脑啡呔
核甘酸
Enkephalin, leucine
Nucleotides
Estrogen
Uterus
