摘要
目的:采用正交设计法筛选生发涂膜剂的最佳制备工艺,并对其进行质量控制。方法:以二苯乙烯苷的含量为评价指标,采用L9(34)正交试验优选该处方的提取工艺条件;以聚乙烯醇124为成膜材料,成膜时间、膜的质量为评价指标,正交试验优选最佳成型工艺条件。结果:生发涂膜剂的最佳提取工艺条件为加8倍量70%乙醇回流提取2次,每次1.5 h;最佳成型工艺条件为中药提取物35 mL,聚乙烯醇124 7 g,甘油2 mL,羧甲基纤维素钠0.75 g。结论:该涂膜剂制备工艺设计合理,制备工艺简单,质量控制方法可靠。
Objective：To select optimum preparation technology and of germinal coating agent and to evaluated its quality control.Method： Optimum extraction technology was optimized by L9（34） orthogonal design experiment with the content of stilbene glucoside as index;with PVA 124 as film forming mateial and film-forming time and film quality as indexes,optimized optimum molding technology by orthogonal design test.Result：optimum extraction conditons of germinal coating agent was：refluxing extracted 2 times with 8 times the amount of 70% ethanol for 1.5 h each time;optimum molding process conditions was：extract of traditional Chinese medicine 35 mL,PVA124 7 g,glycerine 2 mL,sodium carboxymethyl cellulose 0.75 g.Conclusion： Preparation technology of this coating agent was reasonable,simple,and quality control method was reliable.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第5期38-40,共3页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
涂膜剂
正交试验
制备工艺
质量控制
coating agent
orthogonal test
preparation process
quality control
