摘要
[目的]比较口服竹沥胶囊与乙酰半胱氨酸颗粒祛痰作用的临床疗效和安全性.[方法]160例急、慢性支气管炎的患者,随机分为竹沥胶囊组（治疗组）83例,口服竹沥胶囊,0.5 g/次,3粒/次,每日3次,乙酰半胱氨酸组（对照组）77例,口服乙酰半胱氨酸颗粒,0.2 g次,每日3次,两组疗程均为10 d,比较两组的临床疗效.[结果]①临床综合疗效：治疗组和对照组的临床控制率分别为54.2%,54.5%,总有效率分别为89.1%,89.6% ;②祛痰单项指标：治疗组痰液性质、痰量、咳痰难易程度的消失率分别为60.2%,65.1%,55.4%;平均消失天数分别为8.0±2.6,9.1±2.2,9.1±2.8,对照组消失率则分别为59.7%,64.9%,61.0%;平均消失天数分别为8.3±2.7,9.2±2.4,8.4±2.8,两组单项指标症状评分均有所下降.③治疗组与对照组的不良反应发生率分别为4.8%和11.7%,上述各项指标两组相比较均无显著性差异（ P 〉0.05）.[结论]口服竹沥胶囊对急、慢性支气管炎祛痰作用与乙酰半胱氨酸等效,但尚须更为严格的大规模、多中心、双盲临床试验探究.
[Objective] To compare the clinical efficacy and safety of Zhuli capsule vs acetylcysteine granules in trea- ting bronchitis with expectoration. [Methods] Totally 160 patients with chronic bronchitis were randomly divided into Zhuli capsule group（treatment group, n = 83） and acetylcysteine group（control group, n = 77）. The treatment group re- ceived oral Zhuli capsule 0.5g for 3 pills per time and 3 times a day. The control group received oral acetylcysteine gran- ules 0.2g for 3 times a day. Both groups were treated for 10 days. Clinical efficacy was compared between two groups. [Results]The clinical control rate of treatment group and control group were 54.2 % and 54.5 %, respectively. The total efficacy rate of treatment group and control group were 89.1% and 89.6 %, respectively. In treatment group, the disap- pearance rate of sputum properties, the amount of sputum, difficulty of expectoration were 60.2%, 65.1% and 55.4%, respectively, and the average disappearance days were 8. 0 ±2. 6, 9. 1± 2. 2 and 9. 1 ±2. 8, respectively. In control group, the disappearance rate of sputum properties, the amount of sputum, difficulty of expectoration were 59. 7%, 64.9 % and 61.0 %, respectively, and the average disappearance days were 8.3±2.7, 9.2 ±2.4 and 8. 4±2.8, respec- tively. Symptom score of single index in both groups markedly decreased. There was no difference in all indicators be- tween two groups（ P 〉0.05）. The incidence of adverse effect in treatment group and control group were 4.8% and 11. 7%, respectively, but there was no difference between two groups（ P 〉0.05）. [Conclusion] This study indicates that the efficacy of oral Zhuli capsule in treating bronchitis with expectoration is similar to that of acetylcysteine granules. More strict, extensive, multi-center and double-blind clinical trial should be taken.
出处
《医学临床研究》
CAS
2012年第1期88-90,共3页
Journal of Clinical Research
关键词
祛痰
胶囊
乙酰半胱氨酸
Expelling phlegm
capsules
acetylcysteine
