摘要
目的研究红甜菜提取物对人宫颈癌HeLa细胞增殖和对荷瘤小鼠肿瘤生长的抑制作用。方法采用细胞计数法观察红甜菜提取物对HeLa细胞的抑制作用,在人宫颈癌荷瘤鼠模型上观察红甜菜提取物对肿瘤生长的抑制作用,并用病理切片观察瘤体细胞变化。结果甜菜提取物对人宫颈癌HeLa细胞具有抑制作用,并具有剂量-时间依赖关系。荷瘤鼠动物实验表明,红甜菜提取物对裸鼠肿瘤生长也具有抑制作用,剂量为20mg/d时抑瘤率为40%;摄入红甜菜提取物组的裸鼠瘤体细胞出现坏死。结论红甜菜提取物对HeLa细胞的生长和对荷瘤裸鼠肿瘤生长具有抑制作用。
Objective To study the effects of red beet extract on human cervical HeLa cell proliferation and tumor growth in tumor-bearing mice. Methods The inhebition of red beet extract on Hela cell proliferation was determined by cell counting assay; Human cervical carcinoma HeLa cells were treated with red beet extract to detect the inhibition on the tumor growth of human cervical carcinoma HeLa cells in nude mice; The morphogeny of tumor cells was observed with a pathological section. Results The inhibition of red beet extract on HeLa cells was in a time- and dose-dependent manner; The red beet extract could inhibit the growth of HeLa cells in nude mice, the tumor-inhibitary rate （20 mg/d） was 40% for HeLa cells transplanted tumors; There was cell necrosis of the tumor in the groups fed with red beet extract. Conclusion The red beet extract could inhibit the growth of HeLa cells in vitro and the tumor growth in tumor-bearing mice.
出处
《药物评价研究》
CAS
2012年第1期10-13,共4页
Drug Evaluation Research
基金
新疆维吾尔自治区教育厅项目(XJEDU2008120)
关键词
红甜菜
人宫颈癌HELA细胞
裸鼠
肿瘤
red beet
human cervical carcinoma HeLa cells
nude mice
tumors
