摘要
目的:探讨非瓣膜病性心房颤动(AF)患者血清反应蛋白(CRP)、脑钠肽(BNP)与内皮素-1(ET-1)的水平变化及其临床意义。方法:选择持续性房颤患者58例,同时选择性别、年龄、病情等与之相匹配的窦性心律心脏病患者(窦性心律组)55例,测定血清CRP、BNP、ET-1水平并进行统计分析。结果:AF组患者CRP、BNP及ET-1水平均显著高于窦性心律组,差异均具有统计学意义(P<0.01);在相同心功能亚组中,AF组CRP、BNP及ET-1水平均显著高于窦性心律组(P<0.01或P<0.05),且以上指标均随着心功能分级的升高而升高。结论:AF患者血清CRP、BNP及ET-1水平明显升高,并随着心衰程度的加重而升高。
Objective： To investigate the level changes and clinical value of serum-reactive protein（CRP）,brain natriuretic peptide（BNP） and endothelin-1（ET-1） in patients with nonvalvular atrial fibrillation（AF）. Method： 58 patients with AF were included,and selected 55 patients with sinus rhythm who matched with them in gender,age,illness,etc.The levels of serum CRP,BNP,ET-1 were statistically analyzed. Result： The levels of CRP,BNP and ET-1 in AF group were significantly higher than in the sinus rhythm group（P 0.01）;In the same cardiac function subgroup,the levels of CRP,BNP and ET-1 were significantly higher in the AF group than in the sinus rhythm group（P 0.01 or P 0.05）,and the above indicators increased with the increase of severity of cardiac function. Conclusion：The levels of serum CRP,BNP and ET-1 in the patients with AF are significantly higher with more serious of cardiac failure.
出处
《河北医学》
CAS
2012年第2期166-168,共3页
Hebei Medicine
关键词
心房颤动
C-反应蛋白
脑钠肽
内皮素-1
Atrial fibrillation
C-reactive protein
Brain natriuretic peptide
Endot helin-1
