摘要
目的探讨神经型布氏杆菌病的临床特点。方法回顾性分析1例住院患者及29例文献报道神经型布氏杆菌病患者的临床资料。结果本组男23例,女7例;平均发病年龄32岁;16例有接触史,3例食用过生的牛奶和奶制品。脑膜炎(16例,53.3%)和脑膜脑炎(6例,20%)是其最常见的表现形式;布氏杆菌血清凝集试验均为阳性。抗生素治疗6～8周(多西环素、利福平和头孢三嗪、复方磺胺甲基异噁唑、氨基糖苷类、喹诺酮类中的1种)痊愈29例,死亡1例。结论神经型布氏杆菌病需要和许多疾病鉴别,CSF布氏杆菌血清凝集试验可以确诊,多种抗生素长疗程治疗预后较好。
Objective To investigate the clinical features of neurobrucellosis. Methods The clinical data of 1 inpatient and 29 cases derived from China publications were retrospectively analyzed. Results There were 23 males and 7 females. The average onset age was 32 years. Sixteen cases had contact history （53.3%） , and3 cases ate raw milk and milk products （10%）. Meningitis（ 16 cases, 53.3% ） and meningoencephalitis（6 cases,20% ） were the most common form of neurobrueellosis. Brucella serum agglutinin test was positive in all the patients. The combined treatment with antibiotics （ doxycyeline, rifampin and one of Ceftriaxone Sodium or trimethoprim-sulfamethoxazole or aminoglycosides or quinolones ） for 6 - 8 weeks, 29 cases were recure, and 1 case was death. Conclusions Neurobrucellosis need differential diagnosis with many other disease. CSF Brucella serum agglutinin test can diagnosed. Long-term therapy with antibiotics has better prognosis.
出处
《临床神经病学杂志》
CAS
北大核心
2012年第1期43-45,共3页
Journal of Clinical Neurology
