摘要
目的探讨激素对脑死亡猪血流动力学的影响.方法版纳小耳猪14头,随机分为2组,对照组和激素组.用缓慢颅内加压法建立脑死亡模型,激素组予模型建立前半小时6 mg/kg甲泼尼龙琥珀酸钠静脉注入,对照组不用激素.分别予脑死亡后0、1、3、6、9 h监测平均动脉压(MAP)、中心静脉压(CVP)、左室射血分数(LVEF).结果激素组各时段MAP、CVP、LVEF明显高于对照组(P<0.05).结论激素可有效改善脑死亡期心脏的血流动力学.
Objective To investigate the effects of hormonal therapy on the hemodynamics of heart in brain-dead pigs. Methods 14 healthy Xishuangbanna Miniature pigs were divided into two groups： hormone therapy group and control group. Pig brain death model was established by increasing intracranial pressure intermittently and slowly. Pigs in the hormone therapy group were intravenously injected with Methylprednisolone Sodium Succinate （6 mg/kg） half an hour before model establishing, while the pigs in the control group were not given hormone. The MAP, CVP and LVEF were recorded on O, l, 3, 6, 9 hours after brain death. Result The MAP, CVP and LVEF significantly increased in the hormone group, compared with the control group （P 〈 0.05）. Conclusion Hormonal therapy can improve effectively the hemodynamic parameters of heart in the brain-dead pig donor.
出处
《昆明医学院学报》
2012年第1期20-22,共3页
Journal of Kunming Medical College
基金
云南省科技厅-昆明医学院联合专项基金资助项目(2008CD026)
