摘要
结晶提纯5'-胞苷酸二钠的过程存在明显的不确定性和高度的非线性,其中初晶点无法在线检测,给过程优化策略的实施带来了阻碍。利用单纯形法估计出浓液浓度预测模型的参数,通过浓液浓度的变化预测初晶点范围,并建立了关于流加速率对初晶点的模型。模型结果与实验结果基本吻合,建立的模型有效。
The process of crystallizing cytidine-5＇monohposphate disodium salt is significant uncertainty and high nonlinearity. The initial crystallization point can not be detected online, which hinders the implementation of process optimization strategies. In this study,the simplex method was used to estimate the parameters of concentration prediction model, predict the scope of initial crystallization point through the changes in concentrations and establish the model for initial crystallization point versus flow rate finally. The results of model fitting are consistent with the experimental results,which indicates that the model is valid.
出处
《现代化工》
CAS
CSCD
北大核心
2012年第2期85-88,共4页
Modern Chemical Industry
关键词
5’-胞苷酸二钠
结晶
初晶点
动力学模型
流加速率
cytidine-5 ＇ monohposphate disodiumasah
crystallization
initial crystallization point
crystallizationkinetics model
the flow rate
