摘要
为再评价尿蛋白定性定量在糖尿病肾病 (DN)诊断中的价值 ,根据尿常规检查将 1 36例 DN分为尿蛋白阴性组 (41例 )和阳性组 (95例 )两组 ,比较两组间各项临床和生化指标及糖尿病其它并发症发生率的差异。结果 :两组患者血糖和糖化血红蛋白均有升高 ,并以阴性组为甚 (P分别 <0 .0 1和 <0 .0 5 ) ;高血压及糖尿病其它并发症发生率两组均较高 ,尤以阳性组为甚 (P<0 .0 5或 <0 .0 1 ) ,其中高脂血症发生率高达 40 %以上 ,两组无显著性差异 (P>0 .0 5 )。分层分析发现高血压发生率与尿蛋白有相关性 (P<0 .0 1 )。视网膜病变与尿蛋白无关。尿蛋白阴性组氮质血症发生率达 1 7.0 7%。以上提示 :尿蛋白的多少不能完全反映 DN的病程和病变严重程度 ,尿蛋白阴性不能排出 DN的诊断 ,诊断 DN应结合血糖、血脂。
This study was aimed to re evaluate the proteinuria quantitative and qualitative methods for diagnosis of diabetic nephropathy (DN). 136 cases were divided into two groups of proteinuria negativeness and postiveness by the results of urine routine examination. The clinical and biochemical indices and the frequencies of other diabetic complications of the two groups were compared. The results showed that the blood glucose and glycated Hb in the two groups were increased, especially in the proteinuria negative group ( P <0.01 and 0.05, respectively). There was a high prevalence of hypertension and other diabetic complications in the two groups, and it was higher in the positive group than in the negative group ( P <0.05 and 0.01, respectively). The frequencies of hyperlipoproteinemia in the two groups were over 40%, but no significant defference was observed between them ( P >0.05). There was correlation between hypertension and proteinuria ( P <0.01) but no correlation between diabetic retinopathy and proteinuria. The prevalence of azotemia in the proteinuria negative group was 17 07%. These suggest that the amount of proteinuria can not completely reflect the duration and severity of DN. Negative proteinuria in routine examination cannot rule out DN. For diagnosis of DN, it is necessary to think about all data on blood glucose, blood lipid, blood pressure and the change in fundus oculi.
出处
《华西医科大学学报》
CSCD
2000年第1期88-90,共3页
Journal of West China University of Medical Sciences
