摘要
为探讨肺心病患者血清 型前胶原 (PC )、 型胶原 (C )水平的变化 ,采用放射免疫分析法、血气分析仪及肺功能仪 ,分别测定了 2 5例肺心病缓解期患者和 2 0例正常人血清 PC 和 C 含量及血气、肺功能参数。结果显示 :肺心病患者血中 PC 和 C 明显高于正常人 (P<0 .0 1 ) ;PC 和 C 与动脉血氧分压 (Pa O2 )、1秒钟用力呼气量占用力肺活量比值、最大通气量及最大呼气中段流量呈负相关 (P<0 .0 5或 <0 .0 1 )。上述结果表明 ,肺心病患者血清 PC 和 C 含量明显增高 。
This study was conducted to explore the changes of PCⅢ(type Ⅲ procollagen) and CⅣ(type Ⅳ collagen) in the serum in patients with chronic pulmonary heart diseases. The blood levels of PCⅢ and CⅣ in 25 patients with chronic pulmonary heart diseases and 20 normal subjects were measured by radioimmunoassay and were analysed in relation with the artery blood gas and pulmonary function parameters. The results revealed that the blood levels of PCⅢ and CⅣ in the patients were significantly higher than those in normal subjects, and were negatively correlated with PaO 2, FEV 1%, MBC and MMEF ( P<0.05, P<0.01) . The results suggest that the blood levels of PCⅢ and CⅣ of patients with chronic pulmonary heart diseases are significantly increased and significantly correlated with pulmonary function damage and hypoxia.
出处
《华西医科大学学报》
CSCD
2000年第1期75-76,79,共3页
Journal of West China University of Medical Sciences
关键词
前胶原Ⅲ
胶原Ⅳ
肺心病
血气
肺功能
Cor pulmonale\ \ Type Ⅲ procollagen\ \ Type Ⅳ collagen
