摘要
目的:观察白及多糖的抗溃疡作用。方法:采用幽门结扎法、乙酸烧灼法、乙醇损伤法制备大鼠消化性溃疡模型。将实验大鼠随机分成6组,即假手术组、模型组、西咪替丁组及白及多糖高、中、低3个剂量组。阳性组大鼠灌胃给予西咪替丁0.1g/kg,白及多糖高、中、低剂量组大鼠灌胃给予白及多糖400,200及100mg/kg,假手术组、模型组灌胃给予等量生理盐水。按Guth标准记分判定溃疡指数并计算溃疡抑制率。结果:白及多糖对胃溃疡有明显的抑制作用,可促进溃疡大鼠的溃疡愈合,并呈一定的量效关系。
Objective： To study the therapeutic effects of polysaccharides from Bletilla Striata （BSP） on gastric ulcer rats. Methods ： The models of gastric ulcer were established by pylorus - ligation, acitic - acid - firing and alcohol - damage. Experimental SD rats were randomly divided in 6 groups. Each group rats started to be ad- ministrated as fellows. Positive control group received 0. lg/kg Cimetidine （ig）. High, middle and low dose BSP groups received 80, 40 and 20mg/kg BSP （ig）. Sham operation group and negative model group received isovoln- mic normal sodium （ig）. According to Guth - criterion, the ulcer index was determined and the inhibition ratio were calculated. Results： Compared with the model group, BSP inhibited gastric ulcer significantly, and promoted healing of gastric ulcer.
出处
《云南中医学院学报》
2012年第1期30-32,45,共4页
Journal of Yunnan University of Traditional Chinese Medicine
