摘要
目的观察醒鼻凝胶剂对变应性鼻炎(AR)豚鼠的治疗作用。方法以卵清蛋白加氢氧化铝腹腔注射复制豚鼠AR模型,比较6组豚鼠AR的行为学表现,通过Elisa法测定血清中IgE、IL-5、IL-6、TNF-α的含量,HE染色观察鼻黏膜组织病理形态学改变。结果治疗组与模型组相比,豚鼠血清中IgE、IL-5、IL-6、TNF-α的含量明显降低(P<0.01或0.05),HE染色表明醒鼻凝胶剂可显著减轻AR模型豚鼠的鼻黏膜病理改变,鼻黏膜嗜酸性粒细胞计数与模型组比较显著降低(P<0.05)。结论醒鼻凝胶剂有治疗AR豚鼠的作用,其作用机制与抑制IgE及炎性因子IL-5、IL-6、TNF-α的产生有关。
Objective To observe the therapeutical effect of Xingbi nasal gel on guinea pig with allergic rhinitis （AR）. Methods The AR model of guinea pig was established by sensitizing with injection of ovalbumin （OVA） together with aluminium hydroxide. The ethology of guinea pig in six groups was compared, the contents of IgE, IL-5, IL-6 and TNF-ot in blood serum were determined by Elisa method, and the pathomorphology changes of nasal mucosa were observed with HE staining. Results Compared with model group, the contents of IgE, IL-5, IL-6 and TNF-α in blood serum were decreased obviously in treatment groups 5, IL-6 and TNF-α.
出处
《福建中医药大学学报》
2012年第1期36-39,共4页
Journal of Fujian College of Traditional Chinese Medicine
基金
国家自然科学基金项目(81073117/H2812)
福建省高校重点建设项目(2008FG-06)
关键词
醒鼻凝胶剂
变应性鼻炎
豚鼠
炎性因子
Xingbi nasal gel
allergic rhinitis
guinea pig
inflammatory factor
