摘要
[目的]探讨人骨髓核分化抗原(MNDA)在骨肉瘤中的表达及临床意义。[方法]采用免疫组化法检测MNDA在20例骨软骨瘤和42例骨肉瘤组织中的表达,并分析MNDA表达程度与年龄、性别、病理类型和复发、转移等因素的关系。[结果]MNDA在骨肉瘤组的阳性表达率(17%)明显低于骨软骨瘤组(80%)(P<0.01)。MN-DA的阳性表达与性别、年龄无关(P>0.05),与骨肉瘤的病理类型及是否有复发转移相关。[结论]MNDA在骨肉瘤中低表达,为干扰素在骨肉瘤中的研究提供了理论依据。
[Objective]To investigate the expression of myeloid nuclear differentiation antigen（MNDA） in osteosarcoma and analyse its clinical significance in osteosarcoma.[Methods]Immunohistochemical staining was used to detect the expression of MNDA in 42 cases of osteosarcoma and 20 cases of osteochondroma as matched control.[Results]In 42 cases of osteosarcoma,7 were positive for MNDA,and the positive rate was 17%.There was significant difference between osteosarcoma and osteochondroma in MNDA positive expression（P0.01）.The expression of MNDA was related to pathological type,recurrence and metastasis of osteosarcoma,and had no relation to other clinical characteristics,such as patient age and gender.[Conclusion]Low expression of MNDA is found in osteosarcoma,and it provides a basis for the using of interferon in the treatment of osteosarcoma and the study of its anti-tumor mechanism.
出处
《中国矫形外科杂志》
CAS
CSCD
北大核心
2012年第5期445-447,共3页
Orthopedic Journal of China
基金
山东省自然科学基金ZR2009CM042
关键词
MNDA
骨肉瘤
免疫组织化学
myeloid nuclear differentiation antigen
osteosarcoma
immunohistochemistry
