摘要
本实验采用结扎沙土鼠双侧颈总动脉5分钟,然后使血流再通的方法制作迟发性神经元损伤(DND)动物模型。光镜研究结果表明,短时间脑缺血后,沙土鼠脑海马CA_1区神经元损伤发生得极其缓慢,缺血后重灌流至第4天,大部分CA_1区锥体细胞才发生坏死。在亚细胞水平,DND以内质网的大量增生和核蛋白体解聚为其主要特征。这些为DND的典型变化。
Animal model of delayed neuronal death was gerbils subjected to iscbemia for 5min bys bilateral occlusion of the common carotidarteire and then to recirculation from 1h to 21 days. Light miaroscopy Sbowed that CA 1 pyramidal cells developed strikinglya slow cell damaget process. On subcellular level, DND was Characterized by massive growth of the endoplasmicr eliculum and disaggregation of the ribosomes
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
1990年第2期65-66,共2页
Journal of Apoplexy and Nervous Diseases
