摘要
采用双能X线骨密度测定法检测 185例慢性肾衰血透患者的桡骨骨密度 (BMD) ,计算其Z值 ,同时检测其血清甲状旁腺素 (PTH) ,碱性磷酸酶 (ALP)和指骨X照片。结果显示 :血透患者骨密度低于正常对照组 (P <0 .0 5 ) ,并随透析时间延长进一步减低 ;骨密度与其PTH ,ALP和指骨骨膜下吸收呈负相关 ;用Z值对继发性甲状旁腺机能亢进症骨病 (甲旁亢骨病 )作诊断试验 ,受试者运筹特性曲线显示 ,当Z≤ - 2 .2时 ,灵敏度为 79 4 1% ,特异度为 78 15 %。骨密度测定对甲旁亢骨病诊断具有临床应用价值。
The bone mineral density(BMD) and Z score in distal 1/3 radius were measured with dual energy X ray absorptiometry(DEXA) in 185 hemodialysis(HD) patients, meanwhile serum parathyroid hormone(PTH), alkaline phosphatase(ALP) and hand X rays were detected. Results showed that BMD in HD patients was significantly lower than that in control group(P<0.05), and decreased with dialysis duration increasing. BMD in HD patients was negatively related with PTH, ALP and rate of subperiosteal erosions. By using Z score to diagnose hyperparathyroidism bone disease, receiver operating characteristic(ROC) curve was worked out. If Z score≤-2.2, the sensitivity was 79.41% and specificity was 78.15%. In conclusion the measurement of BMD is a useful tool for the detection of hyperparathyroid bone disease. [
出处
《湖南医科大学学报》
CSCD
2000年第1期77-79,共3页
Bulletin of Hunan Medical University
关键词
血液透析
骨密度
甲状旁腺机能亢进
继发性
hemodialysis
bone mineral density
hyperparathyroidism
bone disease,second
