摘要
目的:探讨重组人脑钠尿肽(recombinant human brain natriuretic peptide,rhBNP)对房间隔缺损(ASD)并发肺动脉高压封堵术后的肺动脉高压的影响。方法:选择56例房间隔缺损并发中重度肺动脉高压患者封堵成功患者,将其随机分为术后静脉点滴rhBNP患者为处理组(30例),未应用的为对照组(26例),比较两组术前、术后48 h及术后6个月肺动脉压、6分钟步行试验距离(six minute walking distance,6MWD)、血浆内皮素(endothelin,ET)水平的变化。结果:在术后48 h和术后6个月,两组患者肺动脉压及ET水平术后明显降低(P<0.05);两组患者6MWD较术前显著增加(P<0.05);术后48 h和术后6个月处理组较对照组显著降低肺动脉压及ET水平(P<0.01),显著增加6MWD(P<0.01)。结论:封堵术后静脉点滴rhBNP可进一步降低肺动脉压及ET水平,增加6MWD。
AIM：To investigate the effectiveness of intravenous recombinant human brain natriuretic peptide（rhBNP） on pulmonary hypertension（PH） in patients undergoing transcatheter closure of atrial septal defect（ASD）.METHODS：Fifty-six cases of ASD with PH were treated with transcatheter closure and patients were randomly divided into treatment group（30 patients） and control group（26 patients）.Patients in the treatment group were given rhBNP i.v.after closure of patent ductus arteriosus,and changes of pulmonary artery pressure,endothelin（ET） and 6-min walking distance（6MWD） were tested and compared between groups 48 h and 6 months after treatment.RESULTS：Results were similar in the two groups 48 h and 6 months after treatment.Postoperative levels of pulmonary artery pressure and postoperative ET were significantly lower than preoperative levels（P0.05） and 6MWD increased significantly（P0.05）.However,levels of pulmonary artery pressure and ET of the treatment group were significantly lower than those of the control groups after i.v.administration of recombinant brain natriuretic peptide（P0.01）.6MWD significantly increased compared with that of the control group（P0.01）.CONCLUSION：rhBNP further reduces pulmonary artery pressure and improves cardiac function in patients with PH after transcatheter closure of ASD.
出处
《心脏杂志》
CAS
2012年第1期75-77,81,共4页
Chinese Heart Journal
关键词
重组人脑钠尿肽
房间隔缺损
肺动脉高压
6分钟步行试验距离
recombinant human brain natriuretic peptide
atrial septal defect
pulmonary hypertension
6-minute walking distance
