摘要
目的:观察高敏C反应蛋白(hs-CRP)和氨基末端脑钠尿肽原(NT-proBNP)在急性冠脉综合征(ACS)行急诊冠状动脉介入治疗(PCI)术前后的临床意义及其近期预后的预测价值。方法:选择从2009年2月～2011年4月入住两家医院的ACS患者101例,均已成功行急诊PCI术,术后24 h、72 h～7 d、3～6个月测定血清hs-CRP和NT-proBNP水平;并观察随访3～6个月的主要心脏不良事件(MACE)。同时观察ACS药物治疗组52例,健康对照组40例,并进行对比分析。结果:药物治疗组的近期血清NT-proBNP水平显著高于PCI组;而药物治疗组的72 h～7d的血清hs-CRP水平显著高于PCI组;近期PCI组的MACE事件低于药物治疗组。结论:急诊PCI组3～6个月内治疗效果优于药物治疗组。血清NT-proBNP能够对ACS患者进行危险分层,预测MACE的发生率;hs-CRP可作为行急诊PCI的ACS患者的近期预后的预测因子。
AIM：To investigate the clinical significance and predictive value of high-sensitivity C-reactive protein（hs-CRP） and N-terminal pro-brain natriuretic peptide in patients with acute coronary syndrome（ACS） after primary percutaneous coronary intervention（PCI）.METHODS：We summarized consecutive patients with ACS from February 2007 to April 2011 in Hunan Mawangdui Hospital and Changsha Central Hospital.A total of 101 ACS patients successfully underwent primary PCI and in whom plasma hs-CRP and NT-proBNP were measured,respectively,24 h,72 h-7 days and 3-6 months after PCI.Major adverse cardiac events（MACE） were observed during hospitalization and within 3-6 months after PCI.Plasma hs-CRP and NT-proBNP levels as well as incidence of MACE in 52 ACS patients in medically treated group and 40 healthy controls were also examined during the same period and compared with those in PCI group.RESULTS：Short-term plasma NT-proBNP levels in medically treated group were significantly higher than those in PCI group,but plasma hs-CRP levels within 72 h-7 days were significantly higher in PCI group compared with those in medicine treatment group.MACE in PCI group was lower than that in medically treated group.CONCLUSION：Both plasma hs-CRP and NT-proBNP are good predictors for mortality and MACE incidence in ACS patients treated with PCI or medications.hs-CRP is a short-term prognostic factor for ACS patients treated with primary PCI,whereas NT-proBNP is a long-term prognostic factor for ACS patients.
出处
《心脏杂志》
CAS
2012年第1期63-66,共4页
Chinese Heart Journal
关键词
急性冠脉综合征
高敏C反应蛋白
氨基末端脑钠尿肽原
acute coronary syndrome
high sensitivity C-reactive protein
N-terminal pro-brain natriuretic peptide
