摘要
目的测定乳腺癌患者的血脂相，包括总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆司醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C），以探讨乳腺癌远处转移与血脂异常的关系。方法收集324例乳腺癌患者的临床病理资料和餐前血脂水平，并通过测定血清白蛋白和计算体重指数（BMI）评估患者的营养状态。采用单因素分析和多元Logistic回归法对血脂等临床病理因素与乳腺癌远处转移的关系进行统计学分析。结果单因素分析显示，远处转移组患者的高TC血症、高TG血症、高LDL-C血症和高LDL-C／HDL-C比率高于非远处转移组（P〈0．05）。多元Logistic回归分析显示，肿瘤分期、区域淋巴结转移、高TC血症、高LDL-C血症和高LDL-C／HDL-C比率为乳腺癌发生远处转移的独立危险因素（OR值分别为6．322、4．351、2．324、2．648和4．862）。结论高脂血症与乳腺癌的远处转移密切相关，通过监测血脂相可能有助于预测乳腺癌的远处转移。
Objective In order to investigate whether the presence of distant metastases is associated with serum lipid abnormalities. Methods The fasting serum lipid profile and vrious clinicopathological data of 324 breast cancer patients with and without synchronous distant metastases were collected and analyzed. The serum lipid profile, including total cholesterol （TC）, triglycerides （TG）, low- density （LDL-C） and high-density lipoprotein cholesterol （HDL-C） was determined. The nutritional status, the serum albumin was measured and body mass index （BMI） was calculated. Univariate analysis and multiple logistic regression analysis were carried out to investigate the association of serum lipid profile with distant metastases. Results Univariate analysis showed that the distant metastasis rate was significantly higher in the breast cancer patients with an higher level of serum TC, TG, LDL-C, and LDL-C/HDL-C ratio （ P 〈 0.05 ）. Multiple logistic regression analysis showed that higher serum levels of TC, LDL-C and LDL- C/HDL-C ratio were independent risk factors for distant metastasis in breast cancer （ OR = 2. 324, 2. 648 and 4. 862, respectively ）. Conclusions Hyperfipidemia is significantly associated with the distant metastasis in breast cancer patients. Monitoring of serum lipid profile may be helpful to predict the occurrence of distant metastasis in breast cancer patients.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2012年第2期129-131,共3页
Chinese Journal of Oncology
关键词
乳腺肿瘤
高脂血症
肿瘤转移
危险因素
Breast neoplasms
Hyperlipidemias
Neoplasm metastasis
Risk factors
