摘要
目的探讨急性胰腺炎(AP)患者凝血功能的变化及临床意义。方法选择26例急性水肿型胰腺炎患者(AEP组),21例急性重型胰腺炎患者(SAP组)和30例年龄、性别与体质量指数(BMI)相匹配的健康人(对照组),测定凝血功能血浆凝血酶原时间(PT)、凝血酶原时间国际标准化指数(INR)、部分活化凝血酶原时间(APTT)、纤维蛋白原浓度(FIB)和血小板计数(BPC)并计算24 h内急性生理学与慢性健康状况评分(APACHEⅡ评分),观察并比较上述指标在3组中的不同。结果 SAP组的PT、INR、APTT及FIB均显著高于AEP组和对照组,AEP组的PT、INR、APTT、FIB亦显著高于对照组,差异有统计学意义(均P<0.05)。与对照组相比,SAP组和AEP组的BPC均显著降低(均P<0.05);与AEP组相比,SAP的BPC亦显著降低(P<0.05)。SAP组的A-PACHEⅡ评分显著高于AEP组,差异有统计学意义(P<0.05)。Spearman相关分析显示,AEP组和SAP组的PT、INR、APTT、FIB、BPC均与APACHEⅡ评分呈正相关(均P<0.05)。结论急性胰腺炎患者凝血功能变化与病情严重程度相关。
Objective To investigate the change and clinical significance of coagulation function in patients with acute pancreatitis （AP）. Methods 26 patients with acute edematous pancreatitis（AEP） ,21 patients with severe acute pancreatitis（SAP） and 30 age - ,gender - , body mass index （BMI） - matched healthy subjects were selected from January 2008 to January 2011. The levels of prothrombin time （ PT）, international normalized ratio（INR） ,activated partial thromboplastin time（APTT） ,fibrinogen（FIB） and blood platelet count（BPC） were as- sayed,and the acute physiology and chronic health evaluation（ APACHE Ⅱ ） score was accounted. Observed and compared the difference of a- bove - mentioned indexes. Results The levels of PT,INR,APTT and FIB in SAP group were higher than that in AEP group and control group, the levels of PT, INR, APTT and FIB in AEP group were also higher than that in control group, there was significant difference between three group （all P 〉 0.05 ）. Compared with control group, the levels BPC in SAP group and AEP group were lower. Compared with AEP group, the lev- el of BPC in SAP group was also lower（P 〈 0.05）. The score of APACHE Ⅱ in SAP group was higher than that in AEP group, there was signifi- cant difference between two groups （P 〈 0.05 ）. Spearman correlation analysis displayed that the levels of PT, INR, APTT and FIB in all patients were positively concerned with APACHE Ⅱ （ all P 〈 0. 05 ）, whereas BPC was negatively concerned with APACHE Ⅱ （ P 〈 0. 05 ）. Conclusion The change of coagulation function in patients with AP is related to disease severity.
出处
《河南外科学杂志》
2012年第2期1-3,共3页
Henan Journal of Surgery
关键词
急性胰腺炎
凝血功能
血液
Acute pancreatitis
Coagulation function
Blood
