摘要
目的研究整合素α3β1在食管鳞状细胞癌(ESCC)中的表达及临床意义。方法采用免疫组织化学方法检测135例ESCC及40例正常食管中整合素α3β1的表达。结果在正常食管组织和ES-CC中,整合素α3β1的阳性表达率分别为12.5%(5/40)、82.96%(112/135),其差异有统计学意义(P<0.001)。整合素α3β1的表达与ESCC的TNM分期、肿瘤浸润深度和局部淋巴结转移呈正相关。结论整合素α3β1表达上调能促进ESCC细胞的侵袭和转移。整合素α3β1的表达可应用于临床,作为评估ESCC恶性程度和预测患者预后等的有力指标。
Objective To study the correlation between expression of integrin α3β1 in esophageal squamous cell carcinoma（ESCC）and clinicopathologic conditions.Methods Immunohistochemical assay was used to determine the expression of integrin α3β1 in ESCC（135 cases）,normal esophagus tissues（40 cases）.Results In ESCC,the positive rate of integrin expression was significant higher（82.96%,112/135） than that in normal esophagus tissues（12.5%,5/40）（P0.001）.The expression of integrin α3β1 was correlated to TNM stages,depth of tumor invasion and regional lymph node metastasis.Conclusion The up-regulation of integrin α3β1 in ESCC promoted invasion and metastasis of tumor cells.The expressions of integrin α3β1 could be applied as a cogent indicator clinically to assess the malignant grade of ESCC,and predict prognoses of the patients.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2012年第2期195-197,共3页
Cancer Research on Prevention and Treatment
关键词
食管鳞状细胞癌
整合素Α3Β1
预后
Esophageal squamous cell carcinoma
Integrin α3β1
Prognosis
