摘要
目的探讨Brg1基因的rs12609589和rs73013167两个SNP位点与喉癌发生的相关性。方法选取94例喉癌患者和100例健康对照组,采用PCR-RFLP方法对两位点进行多态性分型,并对结果进行统计学分析。结果 rs12609589位点C、T基因频率在病例组和对照组中无明显差异(P>0.05);rs73013167位点G、C基因频率在病例组和对照组中有差异(P<0.05)。结论 Brg1的rs12609589位点与喉癌的发生没有相关性,rs73013167可能是喉癌发生的易感位点。
Objective To explore the relationship between the single nucleotide polymorphism of Brg1 gene rs12609589 and rs73013167 sites and laryngo carcinoma.Methods Ninety-four sporic laryngo carcinoma patients and 100 controls were collected and DNA was isolated from blood samples.The single nucleotide polymorphism of Brg1 was analyzed using PCR-RFLP.Results No remarkable difference of C and T allele frequencies between case and control groups was observed in rs12609589（P0.05）.In rs73013167,however,the G and C allele frequencies was remarkable difference between case and control groups（P0.05）.Conclusion Brg1 rs73013167 was related to laryngo carcinoma although rs12609589 was not.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2012年第2期130-132,共3页
Cancer Research on Prevention and Treatment
基金
高等学校博士学科点专项科研基金资助项目(20060183040)
关键词
Brg1基因
喉癌
单核苷酸
多态性
Brg1
Laryngo-carcinoma
Single nucleotide
Polymorphism
