摘要
阿尔茨海默病（Alzheimert Sdisease，AD）是一种神经退行性疾病，其临床表现主要是随着年龄增长，学习能力逐渐低下及行为、表达能力等出现障碍。模拟AD疾病病理发展的动物模型是研究此疾病的必要工具。目前已经成功建立了很多转基因动物模型，包括APPPS1，PS1／PS1，Tau蛋白转基因小鼠及快速老化SAMP8小鼠模型。合适的动物模型在AD的病理机制研究及药物研发方面具有极其重要的作用。本文主要综述目前最常见的AD动物模型以及其在药物研发的作用。
Alzheimer＇s disease （Alzheimer＇s disease, AD） is a neurodegenerative disease, its learning ability, behavioral and expression impairments exacerbate with age. AD animal models than simulate the AD disease＇s pathology are an essential tool to study this disease. A number of transgenic animal models had successfully established, including APPPS 1, PS 1/PS 1, Tau protein transgenic mice and rapid aging- SAMP8 mice. Suitable animal model play an important role in the AD pathogenesis and drug development research. This article reviews the most common animal model of AD and its role in drug development.
出处
《实验动物与比较医学》
CAS
2012年第1期80-88,共9页
Laboratory Animal and Comparative Medicine
基金
上海市科委“创新行动计划”（实验动物项目）基金资助（09140901900）和国家科学自然基金面上项目（30970685）
