摘要
目的 应用超声造影技术分析子宫内膜异位症（ endometriosis,Ems）患者在位内膜的血流灌注情况,探寻评价Ems患者在位内膜血管化情况的新方法.方法 选取经临床确诊为Ems的患者30例为研究对象,20例因卵巢良性包块行手术治疗的患者为对照组.所有患者均于月经干净后3～10 d（增生中期至增生晚期）行经阴道超声检查,确认其子宫内膜厚度＞0.3 cm后,注射SonoVue行超声造影,于子宫长轴面上观察子宫内膜的血流灌注情况,造影图像利用脱机分析软件Qontrast分析,得到两组子宫内膜血流灌注的参数：峰值强度（PEAK）、达峰时间（TTP）、局部血容量（RBV）、局部血流量（RBF）,分析两组患者造影参数上的差异性.结果 Ems组在位子宫内膜注冶造影剂后灌注多表现为高增强（26/30）,消退缓慢,对照组子宫内膜注入造影剂后灌注多呈低增强（17/20）,两组比较差异具有统计学意义（P＜0.05）.Ems组造影参数PEAK、TTP、RBV、RBF分别为（41.18±3.29）dB、（29.01±4.46）s、（29.07±4.59） ml、（48.61±5.35） ml/min,而对照组分别为（13.36±2.34）dB、（24.59±2.29）s、（26.51±3.80） ml、（48.71±3.80） ml/min.Ems组PEAK值较正常组明显增高,差异有统计学意义（P=0.000）.结论 超声造影可作为评价Ems患者在位内膜血管化情况的新方法.
Objective To evaluate eutopic endometrial blood supply and vessels in patients with endometriosis（EMs） with contrast enhanced ultrasound （CEUS）,to explore a newmethod to estimate vascularization of eutopic endometrium in EMs patients.Methods Thirty patients with EMs were enrolled and 20 patients who were diagnosed as other gynecological diseases as control.Informed consent of each case was obtained. All cases underwent conventional ultrasound examination and CEUS examination.Characteristics of CEUS in each patients were observed and analyzed using off-line Qontrast software.Parameters of CEUS including peak intensity（PEAK）,time to peak（TTP）,regional blood volume（RBV）,regional blood flow（RBF） were obtained automatically.Results Comparing with control group,the eutopic endometrium in EMs group presented higher enhancement.The parameters of CEUS,including PEAK,TTP,RBV,RBF were （41.18 ± 3.29） dB,（29.01 ± 4.46） s,（29.07 ± 4.59） ml,（48.61 ± 5.35） ml/min in EMs group and （13.36 ± 2.34）dB,（24.59 ± 2.29）s,（26.51 ±- 3.80）ml,（48.71 ± 3.80）ml/min in controls respectively,the value of PEAK in EMs group was higher than that of controls （ P =0.000）.Conclusions CEUS can be regarded as a new method which can be used to assess vascularization of eutopic endometrium in endometriosis.
出处
《中华超声影像学杂志》
CSCD
北大核心
2012年第2期153-155,共3页
Chinese Journal of Ultrasonography
基金
浙江省人口和计划生育科技项目资助（2009,16号）
