摘要
干细胞自我更新及分化潜能一方面是内源性转录因子相互协调控制的结果,另一方面表观遗传修饰也起着重要的作用。该文综述了DNA甲基化修饰的机理、哺乳动物DNA甲基化的特点以及干细胞分化的DNA甲基化修饰。
Stem cells have the ability to self-renew and to differentiate into multiple different cell lineages.On one hand,it is because of the intercoordinations of endogenous transcription factors;on the other hand,epigenetics modification plays an important role.This paper reviewed the mechanism of DNA methylation,the feature of DNA methylation in mammalian stem cells and the DNA methylation modification during stem cell differentiation.
出处
《中国细胞生物学学报》
CAS
CSCD
北大核心
2012年第2期185-189,共5页
Chinese Journal of Cell Biology
基金
国家自然科学基金(No.31070878)资助项目~~
关键词
干细胞分化
表观遗传
DNA甲基化
stem cell differentiation
epigenetics
DNA methylation
