摘要
目的 探讨抗血管紧张素Ⅱ1型受体自身抗体（AT-AA）与冠脉介入治疗（PCI）术后再狭窄形成的关系。方法选择既往行PCI治疗的冠心病患者67例，根据冠脉造影结果分为再狭窄组（35例）及非再狭窄组（32例）；另选择对照组26例。应用酶联免疫吸附测定（ELISA）技术检测三组患者血清AT1-AA。结果再狭窄组患者血清AT1-AA阳性率高于非再狭窄组（45．7％比21．9％，P〈0．05）及对照组（45．7％比11．5％，P〈0．01）。结论AT1-AA可能参与PCI术后再狭窄发生、发展的病理生理过程。
Objective This study will explore the role of autoantibodies against AT1-receptor （AT1-AA） in the development of patients with restenosis after percutaneous coronary intervertion （PCI）. Methods Select 93 hospitalized patients who include control （n=26） and patients with coronary heart disease accepted PCI previously who according to the results of coronary angiography were divided into restenosis（n=35） and no restenosis（n=32）. The epitope of the 2nd extracellular loop of type 1 angiotensin （AT1 receptor were synthesized and used as antigens to screen the autoantibodies against AT1-receptor in the serum of all patients by ELISA. Results Patients with restenosis, the positive rates of autoantibodies against AT1-receptor were higher than without restenosis （45.7% vs 21.9%, P〈0.05） and controls （45.7% vs 11.5%, P〈0.01）. Conclusion Autoantibodies against ATreceptor might play a role in the pathophysiological process of restenosis after PCI.
出处
《中国心血管病研究》
CAS
2012年第2期119-122,共4页
Chinese Journal of Cardiovascular Research
