摘要
以香兰素为原料对天然产物(E)-4-(3-溴-4,5-二羟基苯基)-3-丁烯-2-酮进行有机合成的研究。经过了溴代、羟醛缩合和脱甲基三个步骤。得到衍生物(E)-4-(3-溴-4羟基-5-甲氧基苯基)-3-丁烯-2-酮,为天然产物(E)-4-(3-溴-4,5-二羟基苯基)-3-丁烯-2-酮的全合成提供了新方法。涉及的化合物结构经过IR,1HNMR确证。
Vanillin as raw material,studied the whole thesis of a natural product—(E)-4-(3-bromo-4,5-dihydroxyphenyl)-but-3-en-2-one is used.The route was consist of three parts:bromination,aldol condensation and demethylation,through which(E)-4-(3-bromo-4-hydroxy-5-methoxyphenyl)-but-3-en-2-one was synthesized.A new method about the whole thesis of(E)-4-(3-bromo-4,5-dihydroxyphenyl)-but-3-en-2-one is also given.The bromophenols mentioned above are identified by IR or 1HNMR.
出处
《科学技术与工程》
北大核心
2012年第4期926-928,共3页
Science Technology and Engineering
