1Jeppsson B,Freund HR,Gimmon Z,et al.Blood-brain barrier derangement in seosis:cause of septic encephalopathy?[J].Am J Surg,1981,141(1):136-142.
2Pendlebury WW,Perl DP,Munoz DG.Multiple miemabscesses in the central nervous system:a clinicopathologic study[J].J NeumpathoI Exp Neurol,1989,48(3):290-300.
4Semmler A,Okulla T,Sastre M,et al.Systemic inflammation induces apsptosis witll variable vulnerabilibity of different brain regions[J].J Chem Neuroanat,2005,30(2-3):144-157.
5Comim CM,Constantino LC,et al.Cognitive impairment in the septic brain[J].Curr Neurovasc Res,2009,6(3):194.
6Pytel P,Alexander JJ.Pathogenesis of septic encephalopathy[J].Curr Opin Neurol,2009,22(3):283-287.
7Lin SM,Huang CD,Liu CY,et al.Risk factors for the development of early-onset delirium and the subsequent clinical outcome in mechanically ventilated patients[J].J Crit Care,2008,23(3):372-379.
8Wratten ML.Therapeutic approaches to reduce systemic inflammation in septic-associated neurologic complications[J].Eur J Anaesthesiol Suppl,2008,42:1-7.
9Siami S,Annane D,Sharshar T.The encephalopathy in sepsis[J].Crit Care Clin,2008,24(1):67-82.
10Bleck TP,Smith MC,Pierre-Louis SJ,et al.Neurologic complications of critical medical ilnessess[J].Crit Care Med,1993,21(1):98-103.
二级参考文献45
1Alexander JJ,Jacob A,Cunningham P,et al.TNF is a key mediator of septic encephalopathy acting through its receptor,TNF receptor-1[J].Neurochem Int,2008,52(3):447-456.
2Hofer S,Bopp C,Hoerner C,et al.Injury of the blood brain barrier and upregulation of icam-1 in polymicrobial sepsis[J].J Surg Res,2008,146(2):276-281.
3Levy RJ,Dautschman CS.Cytochrome c oxidase dysfunction in sepsis[J].Crit Care Med,2007,35(9 Suppl):468-475.
4Basler T,Meier-Hellmann A,Bredle D,et al.Amino acid imbalance early in septic encephalopathy[J].Intensive Care Med,2002,28 (3):293-298.
7Lopez A,Lorente JA,Steingrub J,et al.Multiplecenter,randomized,placebocontrolled,double-blind study of the nitric oxide synthase inhibitor 546C88:effect on survival in patients with septic shock[J].Crit Care Med,2004,32 (1):21-30.
4Scicluna BP, van der Poll T. Interleukin-27: a potential new sepsis biomarker exposed through genome-wide transcriptional profiling[J]. Crit Care, 2012, 16(6): 188.
5Wong HR, Cvijanovich NZ, Hall M, et al. Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children[J]. Crit Care, 2012, 16(5): R213.
6Wong HR, Liu KD, Kangelaris KN, et al. Performance of inter-leukin-27 as a sepsis diagnostic biomarker in critically ill adults [J]. J Crit Care, 2014, 29(5): 718-722.
