摘要
目的分析大规模人群应用甲型H1N1流行性感冒疫苗后的预防接种不良反应特征,进一步观察该疫苗的安全性。方法通过国家疑似预防接种异常反应监测系统,收集广州市2009年10月28日~2010年8月31日期间的甲型H1N1流感疫苗接种信息和接种后疑似预防接种不良反应个案数据,分析相关特征。结果共接种575 412人,报告183例预防接种不良反应,不良反应发生率为31.80/10万,其中异常反应发生率为5.39/10万;52.5%的不良反应发生在接种疫苗后24 h内,以发热、红肿多见,多数不良反应预后良好。接种疫苗后出现急性播散性脑脊髓炎2例,为13岁及15岁男孩各1名,其中1例死亡。结论大规模接种甲型H1N1流感疫苗后预防接种不良反应的发生率低,但需警惕严重不良反应的发生。
Objective To analyze the characteristics of post licensure adverse reaction following influenza A（H1N1） vaccine immunization and to observe the further safety.Methods Relevant data were collected from National Immunization Information System.Data during Oct 28th 2009 to Aug 31th 2010 in Guangzhou were analyzed.Results 575 412 immunization cases were reported,including 183 cases with adverse reactions following immunization,with the incidence rate of 31.8 and rare adverse reaction of 5.39 per 100 000 doses.52.5% of reactions occurred within 24 hours post-vaccination.The clinical features of adverse reaction following influenza A（H1N1） vaccine immunization primarily included fever,local redness and swelling;however,all the cases exhibited improved prognosis.Two boys aged 13 and 15 respectively were diagnosed as acute disseminated encephalomyelitis following influenza A（H1N1） vaccination.Conclusions A low incidence rate of adverse reaction following influenza A（H1N1） vaccine immunization was observed in the large scale inoculation,however,monitoring for serious adverse reactions is recommended.
出处
《中华疾病控制杂志》
CAS
北大核心
2012年第2期145-148,共4页
Chinese Journal of Disease Control & Prevention
基金
广东省医学科研基金(A2011506)
广州市医药卫生科技项目(201102A213026)
关键词
流感疫苗
接种
监测
免疫学
流行病学研究
Influenza vaccine
Vaccination
Monitoring
immunologic
Epidemiologic studies
