摘要
对蝎毒治疗白血病的机制进行阐述,蝎毒蛋白是蝎毒主要的活性成分,蝎毒能诱导人白血病K562细胞,HL-60细胞,Raji细胞凋亡,其作用机制可能与提高P53基因,降低Bcl-2基因表达有关。蝎毒及其分离组分通过减少白血病细胞从骨髓内的逸出,抑制白血病细胞对血管内皮细胞的粘附及跨血管迁移,干预白血病细胞对细胞外基质的降解等方面干预白血病髓外浸润。同时蝎毒组分具有改善骨髓造血抑制,恢复免疫功能的作用。蝎毒是一种具有开发应用前景的抗白血病药物。
Objective：Scorpion venom on the mechanism described the treatment of leukemia, scorpion venom scorpion venom protein is fiae main active ingredient, scorpion venom can induce human leukemia K562 cells, HL-60 cells, Raji cells, its mechanism and improving the P53 gene may reduce the Bcl-2 gene expression. Scorpion venom and its fractions by reducing the leukemic ceils escape from the bone marrow, inhibition of leukemic ceils to vascular endothelial cell adhesion and migration across the vascular intervention leukemia cells to extracellular matrix and other aspects of intervention to lower extramedullary leukemic infiltration. Scorpion venom components have also improved bone marrow suppression, restoring immune function. Scorpion venom is a prospect with the development and application of anti-leukemia drugs.
出处
《内蒙古中医药》
2012年第2期114-116,共3页
Inner Mongolia Journal of Traditional Chinese Medicine
关键词
蝎毒
白血病
机制
scorpion venom
Leukemia
Mechanism
