摘要
目的探讨不同剂量瑞舒伐他汀对于SAA、hs-CRP的影响,以及两种炎症标记物对血管内炎症特异性检测的比较。方法将普通级SD雄性大鼠进行高脂饮食建立AS模型,后随机予以高剂量喂药、低剂量喂药、无喂药,共4周。检测不同时段SAA、hs-CRP的水平。结果高脂饮食后SAA、hs-CRP水平较之前明显升高;喂药4周后,SAA和hs-CRP水平为:模型组高于另外两组,低剂量组高于高剂量组。在AS血管慢性炎症情况下,SAA与hs-CRP呈正相关性,相关系数r=0.375,(P<0.01)。结论不同剂量瑞舒伐他汀的抗炎作用与其剂量使用存在量-效关系;血清SAA、hs-CRP的水平随AS进程不断升高,而SAA对于慢性血管内炎症检测特异性高于hs-CRP。
Objective To investigate the effects of different doses of rosuvastatin for SAA, hs-CRP effects, and two inflammatory markers of vascular inflammation in the specificity of the detection of comparison. Methods The common SD male rats were fed with high fat diet to establish AS model, after randomization to high dose, low dose of medicine medicine, no medicine, a total of 4 weeks. Detection of SAA, hs-CRP levels in different periods. Results Of high fat diet after SAA, hs-CRP levels were significantly elevated the medicine before; after 4 weeks, SAA and hs-CRP level is higher than the other two groups： model group, low dose group were higher than those in the high dose group. In atherosclerotic vascular chronic inflammatory conditions, SAA and hs-CRP positive correlation, the correlation coefficient r = 0.375, （ P 0.01 ）. Conclusion Different dose of rosuvastatin anti-inflammatory effect and dose using existing dose-effect relationship; serum SAA, hs-CRP levels with the atherosclerotic process continuously increased, and SAA for chronic vascular inflammation detection of specific than hs-CRP.
出处
《当代医学》
2012年第5期131-132,共2页
Contemporary Medicine
