摘要
目的探讨血清和腹水AFP、CEA、CA125、CA19-9对良、恶性腹水鉴别诊断的价值。方法 70例腹水患者根据病因分为良性组和恶性组,比较2组患者血清和腹水肿瘤标志物的水平。结果恶性组血清和腹水中AFP、CEA、CA19-9水平均高于良性组(P均<0.05)。血清AFP、CEA、CA19-9联合检测的敏感性、特异性和准确性分别为61.90%、82.14%和70.00%,腹水AFP、CEA、CA19-9联合检测的敏感性、特异性和准确性分别为57.14%、88.46%和67.14%。结论血清和腹水AFP、CEA、CA19-9的检测有助于良、恶性腹水的鉴别,血清或腹水AFP、CEA、CA19-9联合检测可提高恶性腹水诊断的敏感性和准确性。
Objective To investigate the value of AFP,CEA,CA125 and CA19-9 in serum and ascitic fluid for the differential diagnosis of benign and malignant ascites. Methods The 70 patients with ascites were divided into the benign group and the malignant group according to their etiology.The levels of tumor makers in serum and ascitic fluid were measured and compared. Results The AFP,CEA and CA19-9 levels in serum and ascitic fluid of the malignant group were higher than those of the benign group（P0.05）.The sensitivity,specificity and accuracy of combined detection of AFP,CEA and CA19-9 in serum were 61.90%,82.14% and 70.00%,respectively;and those in ascitic fluid were 57.14%,88.46% and 67.14%,respectively. Conclusion It is helpful to detect AFP,CEA,CA19-9 in serum and ascitic fluid for the differentiation of benign and malignant ascites;the sensitivity and accuracy of diagnoses of malignant ascites can be increased by the combined detection of AFP,CEA and CA19-9 in serum or ascitic fluid.
出处
《肿瘤基础与临床》
2012年第1期47-49,共3页
journal of basic and clinical oncology
关键词
腹水
鉴别诊断
肿瘤标志物
ascites
differential diagnosis
tumor markers
