摘要
目的探讨结直肠癌患者外周血CD4+CD25high调节性T细胞(Treg)的作用。方法采用流式细胞仪测定36例结直肠癌患者及30例健康对照者外周血中CD4+CD25highFoxP3 Treg、CD4+CD25highTreg、CD4+CTLA-4 Treg及CD4+T细胞水平。结果与健康对照组比较,结直肠癌组患者外周血CD4+CD25highFoxP3 Treg显著增多(P<0.01),CD4+CD25high Treg和CD4+CTLA-4 T细胞也增多(P<0.05)。结论CD4+CD25highFoxP3 Treg可能在结直肠癌发展过程中起着重要作用。
Objective To evaluate the action of peripheral CD4＋CD25high Treg in peripheral blood of patients with colon cancer. Methods The 36 patients with colon cancer and 30 healthy controls were studied.The CD4＋CD25highFoxP3 Treg,CD4＋CD25high Treg,CD4＋CTLA-4 Treg and CD4＋ T cells in peripheral blood were measured with flow cytometry. Results A significant difference of CD4＋ CD25＋ FoxP3 Treg cell was found between the patients with colon cancer and the healthy controls（P0.01）.There were signifigant differences of CD4＋CD25high Treg and CD4＋CTLA-4 T cells between the patients with colon cancer and the healthy controls（P0.05）. Conclusion CD4＋CD25highFoxP3 Treg may play a significant role in the development of colon cancer.
出处
《肿瘤基础与临床》
2012年第1期14-17,共4页
journal of basic and clinical oncology
