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脑卒中后抑郁早期干预对神经功能康复的影响 被引量:1

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摘要 目的对脑卒中后抑郁患者进行早期干预,观察对神经功能康复的影响。方法将66例2008年6月至2011年6月的脑卒中后抑郁患者按患者意愿分成治疗组36例,对照组30例。全部病例均进行常规药物治疗和康复训练。治疗组加用氟西汀20 mg口服,1次/d,共4周。所有患者在治疗前及治疗4周后应用汉密尔顿抑郁量表(HAMD)以及Zung抑郁自评量表评分评估抑郁、应用Barthel指数评估日常生活活动能力、用神经功能缺损程度评分测评神经功能缺损程度。结果治疗组总有效率83.0%,对照组为73.0%,两组总有效率比较差异显著(P<0.01),治疗4周后,神经功能缺损评分比较,治疗组与对照组均有明显改善(P<0.01),治疗组4周后HAMD≥17分者为2例,抑郁发生率为5.6%,对照组4周后HAMD≥17分者6例,抑郁发生率为20.0%,差异亦有显著性意义(P<0.01),治疗组未发现明显不良反应。结论积极的早期干预对脑卒中后抑郁的神经功能康复有显著意义。
出处 《临床和实验医学杂志》 2012年第4期307-307,309,共2页 Journal of Clinical and Experimental Medicine
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