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足细胞相关蛋白对糖尿病肾病的影响 被引量：4

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摘要 近年来的研究证实在糖尿病肾病发生、发展过程中,足细胞在其中起着关键的作用。在高血糖,TGFβ-和血管紧张素Ⅱ等致病因素作用下,足细胞裂孔隔膜蛋白、细胞骨架蛋白及细胞骨架与裂孔隔膜之间紧密连接蛋白和顶膜区蛋白表达的改变,继而出现足突融合,足细胞从基底膜上脱离,肾小球滤过屏障通透性增高等结构改变,促进局灶节段性肾小球硬化的发生,肾功能下降,出现蛋白尿。研究足细胞相关蛋白分子的表达改变及相应的逆转措施可为糖尿病肾病早期防治带来新的希望。
作者 李思佳 刘育军
机构地区 上海中医药大学 上海中医药大学附属普陀医院肾内科
出处 《长春中医药大学学报》 2012年第1期141-144,共4页 Journal of Changchun University of Chinese Medicine
基金 上海市教委创新课题基金资助项目(No.09YZ133)
关键词 足细胞 糖尿病肾病 蛋白尿
分类号 R589.1 [医药卫生—内分泌]
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参考文献30

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共引文献20

同被引文献58

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引证文献4

二级引证文献32

长春中医药大学学报
2012年 第1期

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