摘要
目的采用现场即时检测血凝仪对长期口服抗凝药物患者国际标准化比值进行监测,并与常规方法进行比较,初步探讨现场即时检测血凝仪的临床应用。方法应用英锐抗凝监测仪及中心实验室2种方法分别对因心房颤动、心脏瓣膜手术住院治疗并口服抗凝药物(华法林)的120例患者的国际标准化比值进行检测,采用Kappa检验和Bland-Altman分析对2种检测结果的一致性进行比较。结果 Kappa检验对2种方法所测国际标准化比值结果高度一致,Kappa值为0.796;Bland-A1tman分析显示,2种方法所测平均偏差为(0.41±0.04),一致性界限为0.328～0.499,具有较好一致性。结论现场即时检测血凝仪可以在临床上与中心实验室检测互相替代使用,尤其适用于行动不便长期口服抗凝药物患者进行家庭自测。
Objective Use the portable prothrombin time monitors,which belongs to the Point-of- Care Systems, to monitor INR for patients treated with long-term oral anticoagulants; then make a comparison between portable and laboratory coagulation analyzers,and perform preliminary analysis on clinical application of portable prothrombin time monitors. Methods During the period from Apr. 2010 to Feb. 2011,120 inpatients with atrial fibrillation or heart valve surgery, who were treated with long-term oral anticoagulants and agreed to join in the study ,were enrolled. We used both INRatio and laboratory coagulation analyzers to measure all patients＇ INR. Data were collected,Kappa test and Bland-Altman plot were then used to analyze the consent＇us of the re-sults obtained by INRatio and laboratory coagulation analyzers. Results Kappa value was 0. 796,indicating the observed value of of portable coagulation analyzer was highly coincident with the obrved value of laboratory coagulation analyzer.Conclusion Portable coagulation analyzer could used in any clinical seting,such as hospital, patient＇s house, to substitute for laboratory coagulatn analyzer.And the patients who have difficulties in movements or have not enough time to go hospital,can perform INR self-testing.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2012年第2期132-134,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
