摘要
目的:研究刺五加与五味子合用后对小鼠的镇静催眠作用。方法:采用阈上和阈下剂量戊巴比妥钠致小鼠睡眠法,对刺五加和五味子单用及合用的镇静催眠作用进行比较研究。应用戊巴比妥钠所致小鼠睡眠的方法,研究刺五加和五味子改善睡眠作用的量效关系。结果:刺五加可以延长睡眠时间(P<0.01),起效剂量为16g/kg,起效范围为16～128g/kg,其中剂量为64g/kg时效果最为显著。五味子可以缩短睡眠潜伏期(P<0.05),起效剂量为3g/kg,起效范围为3～12g/kg,其中剂量为12g/kg时效果最为显著。与空白组相比,刺五加与五味子合用组可显著缩短戊巴比妥钠小鼠的入睡潜伏期(P<0.01)并能延长其睡眠时间(P<0.01),能明显增加阈下剂量戊巴比妥钠小鼠的入睡率(P<0.05)。其作用优于单用刺五加组和单用五味子组。结论:刺五加与五味子合用具有镇静催眠的作用。
Objective：To study the sedative and hypnotic effect of Acanthopanax senticosus combined with Schisandra chinensis in mice.Methods：Study the dose-effect relationship on Acanthopanax senticosus and Schisandra chinensis in the effect of improving sleep.By inducing dormancy of the mice with subliminal and suprathreshold dose of sodium pentobarbital adding the herbs to evaluate the sedative and hypnotic effect of these two herbs used alone or together.Results：The best dose of Acanthopanax senticosus（16~128g/kg）which prolonged the time of falling asleep（P0.01）in mice was 64g/kg.The best dose of Acanthopanax senticosus（3~12g/kg）which shortened the duration sleep latency（P0.05）in mice was 12g/kg.Contrasting to the blank group,Acanthopanax senticosus combined with Schisandra chinensis could reduce the latent period of falling asleep（P0.01）,prolong the sleep time induced by sodium pentobabital（in suprathreshold dose）（P0.01）,and remarkedly enhance the rate of falling asleep induced by sodium pentobabital（in subthreshold dose）（P0.05）.Its effect is superior to the effect of Acanthopanax senticosus or Schisandra chinensis.Conclution：Acanthopanax senticosus combined with Schisandra chinensis had obvious effects on the sedation and hypnosis of mice.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2011年第6期66-68,共3页
Pharmacology and Clinics of Chinese Materia Medica
基金
哈尔滨市科技创新人才研究专项资金项目(No.2008RFXXS041)
关键词
刺五加
五味子
镇静催眠
Acanthopanax senticosus
Schisandra chinensis
sedative and hypnotic
