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高血压、吸烟与年龄相关白内障关联性研究 被引量:4

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摘要 目的:探讨高血压、吸烟与年龄相关白内障(ARC)的关系。方法:采用以医院为基础的病例对照研究方法,病例组为2009年10月至2011年3月施行白内障摘除术,年龄45~85岁的260例患者;对照组为与病例同期入住相同医院的260例罹患其他疾病的患者,病例与对照采取1∶1匹配。应用自行设计的健康状况调查表进行调查,调查内容主要包括一般人口学特征、生活方式(吸烟)以及个人疾病既往史等。同时还对研究对象的血压进行测量。采用多因素Logistic回归模型估计高血压、吸烟与ARC关联的比值比(OR)及其相应的95%CI。结果:调整年龄、性别因素后,高血压与ARC呈正相关(OR=1.533,95%CI:1.057~2.223,P=0.024)。高血压病程≥20年者发生ARC的危险性显著增加(OR=2.418,95%CI:1.065~5.491,P=0.035)。与从不吸烟者相比,吸烟≥30支/d者发生ARC的OR为2.120(95%CI:1.039~4.326,P=0.039)。吸烟量越大,发生ARC的危险性越高。吸烟≥30年者发生ARC的危险性比不吸烟者增加51.2%(OR=1.512,95%CI:1.006~2.272,P=0.047)。与现行吸烟者相比,戒烟≥10年的研究对象发生ARC的危险性显著降低(OR=0.437,95%CI:0.195~0.980,P=0.041)。结论:高血压、吸烟是ARC发生的重要危险因素,控制高血压、尽早戒烟可有助于延缓ARC的发生发展。
出处 《广西医科大学学报》 CAS 2011年第6期885-887,共3页 Journal of Guangxi Medical University
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