期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Tissue plasminogen activator-independent roles of neuroserpin in the central nervous system

在线阅读 下载PDF
导出
摘要 A number of studies have confirmed the existence of tissue-type plasminogen activator-independent roles of neuroserpin,a member of the serine protease inhibitor superfamily.In this review article,we aim to clarify this role.These unique roles of neuroserpin are involved in its neuroprotective effect during ischemic brain injury,its regulation of tumorigenesis,and the mediation of emotion and cognition through the inhibition of urokinase-type plasminogen activator and fibrinolysin,modification of Th cells,reducing plaque formation,promoting process growth and intracellular adhesion,and alterina the expression of cadherin and nuclear factor kaooa B.
作者 Jiao Ma Yu Tong Dan Yu Meng Mao
机构地区 Department of Pediatrics Key Laboratory of Obstetric&Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education Laboratory of Early Developmental and Injuries
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第2期146-151,共6页 中国神经再生研究(英文版)
基金 supported by the National Natural Science Foundation of China,No.30700908,30772343 and 30973215
关键词 NEUROSERPIN tissue-type plasminogen activator SERPIN cerebral ischemia tumor familial encephalopathy with neuroserpin inclusion bodies
分类号 Q949.753.5 [生物学—植物学] Q426 [生物学—神经生物学]
  • 相关文献

参考文献59

  • 1Ruegg MA, Stoeckli ET, Kuhn TB, et al. Purification of axonin-1, a protein that is secreted from axons during neurogenesis. EMBO J. 1989;8(1):55-63.
  • 2Hastings GA, Coleman TA, Haudenschild CC, et al. Neuroserpin, a brain-associated inhibitor of tissue plasminogen activator is localized primarily in neurons. Implications for the regulation of motor learning and neuronal survival. J Biol Chem. 1997;272(52): 33062-33067.
  • 3Osterwalder T, Contartese J, Stoeckli ET, et al. Neuroserpin, an axonally secreted serine protease inhibitor. EMBO J. 1996;15(12): 2944-2953.
  • 4Berger P, Kozlov SV, Cinelli P, et al. Neuronal depolarization enhances the transcription of the neuronal serine protease inhibitor neuroserpin. Mol Cell Neurosci. 1999;14(6):455-467.
  • 5Krueger SR, Ghisu GP, Cinelli P, et al. Expression of neuroserpin, an inhibitor of tissue plasminogen activator, in the developing and adult nervous system of the mouse. J Neurosci. 1997;17(23): 8984-8996.
  • 6Yamada M, Takahashi K, Ukai W, et al. Neuroserpin is expressed in early stage of neurogenesis in adult rat hippocampus. Neuroreport. 2010;21(2):138-142.
  • 7Sumi Y, Dent MA, Owen DE, et al. The expression of tissue and urokinase-type plasminogen activators in neural development suggests different modes of proteolytic involvement in neuronalgrowth. Development. 1992;116(3):625-637.
  • 8Yepes M, Lawrence DA. Tissue-type plasminogen activator and neuroserpin: a well-balanced act in the nervous system? Trends Cardiovasc Med. 2004;14(5):173-180.
  • 9Yepes M, Lawrence DA. New functions for an old enzyme: nonhemostatic roles for tissue-type plasminogen activator in the central nervous system. Exp Biol Med. 2004;229(11):1097-1104.
  • 10Huang YY, Bach ME, Lipp HP, et al. Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late-phase long-term potentiation in both Schaffer collateral and mossy fiber pathways. Proc Natl Acad Sci U S A. 1966;93(16):8699-8704.
Neural Regeneration Research
2012年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部