摘要
目的探讨纳洛酮联合喹硫平与单用喹硫平治疗痴呆叠加谵妄的疗效与疗效指数。方法符合DSM-4痴呆叠加谵妄（DSD）诊断标准的住院病人70例，随机分成治疗组（纳洛酮联合喹硫平）35例和对照组（喹硫平）35例，前瞻性观察治疗15天，采用谵妄量表（DSS）在治疗前及治疗3、6、9、12、15天进行评分。采用简易智力状态量表（MMSE）、日常生活评定量表（ADL）及临床疗效总评量表（CGI）在治疗前和治疗15天后进行评分。结果治疗组与对照组治疗DSD均有效，疗效指数高（CGI-G1分别为1．46±0．51、1．66±0．48，CGI-E1分别为3．24±0．83、2．83±0．84）。治疗组在治疗3、6、9、12、15天DSS评分增加分与对照组比较差异有统计学意义（P〈0．05或〈0．01），治疗后MMSE增加分和CGI—EI增加分与对照组比较差异亦有统计学意义（P〈0．05）。结论在治疗痴呆叠加谵妄时，纳洛酮联合喹硫平较单用喹硫平控制谵妄症状快，疗效指数高，可提高认知功能。
Objective To explore the efficacy and efficacy index of DSD treatment with Naloxone joint Quetiapine and Quetiapine alone. Methods 70 patients with delirium superimposed on dementia （DSD） were randomly divided into Quetiapine group（n = 35 ） and Naloxone joint Quetiapine group（ n = 35 ）, prospective observation treatment continued for 15 days. before and after treatment, DSS, MMSE, ADL and CGI were respectively used to evulate. Results Both Naloxone joint Quetiapine and Quetiapine alone to therapy DSD are effective and their efficacy index are high（ CGI-GI： 1.46±0.51,1.66±0.48, CGI- E1：3.24±0.83,2.83±0.84 ）. Comparing two groups, after treatment for 3 days, 6 days, 9 days, 12 days, 15 days the Dss increase points of Naloxone joint Quetiapine group was significant statistically（P 〈 0.01 or P 〈 0. 05 ）. After treatment, MMSE and CGI-EI increase points of Naloxone joint Quetiapine group have statistically significance （P 〈 0.05 ）. Conclusion Comparing to Quetiapine alone, Naloxone join Quetiapine to treat delirium superimposed on dementia can control delirium faster,has a higher efficacy index and improve cognitive function.
出处
《临床内科杂志》
CAS
2012年第1期37-39,共3页
Journal of Clinical Internal Medicine
基金
广东省佛山市卫生局科研基金项目（2009075）
关键词
纳洛酮
喹硫平
痴呆叠加谵妄
疗效
疗效指数
Naloxone
Quetiapine
Delirium superimposed on dementia
Efficacy
Efficacy index
