摘要
海洋占地球表面积的大约四分之三,那里栖息的生物物种构成的生物学与化学的多样性,使海洋有可能成为抗肿瘤药物的来源,因此,从海洋中寻找和开发抗肿瘤药物是一个前途广阔的新领域。近十几年来,已从不同的海洋生物中分离鉴定了许多结构新颖的抗肿瘤活性物质,这些药物表现出的抑制增殖和诱导细胞凋亡能力,对已有的抗癌药物而言,极大补充了它们的作用,显示出诱人的研究开发前景。本文拟结合国内外文献报道阐述从海洋动物、海洋植物和海洋微生物抗肿瘤活性物质的研究开发进展。
Oceans and seas comprise approximately three quarter of the global surface,and the organisms dwelling there contribute to the biological and chemical diversity of the marine environment,which forms the source of antitumor drugs.The search and development of new drugs using the materials has become intriguing and promising.In the recent years,a number of antitumor bioactive substances with novel structure have been identified from marine organisms.Their potentials to inhibit cellular proliferation and to trigger apoptosis are complementary to the currently used anticancer drugs,thus warrant further pharmacologic investigation and clinical trials in the future.In the present review,advances and trends in the research and development of the drugs derived from marine animals,plant and microbes are to be discussed based on the findings of the available literatures.
出处
《海南医学》
CAS
2012年第2期118-121,共4页
Hainan Medical Journal
基金
东莞市高等院校科研机构科技计划项目(编号:200910815265
2008108101035)
关键词
抗肿瘤活性物质
海洋动物
海洋植物
海洋微生物
Antitumor bioactive substances
Marine animal
Marine plant
Marine microbes
