摘要
为探讨ｂｃｌ－ ２ 和ｐ５３ 蛋白在非小细胞肺癌中表达之间的关系及意义，应用免疫组织化学Ｓ－ Ｐ法对６２ 例非小细胞肺癌组织进行检测。结果发现：⑴ｂｃｌ－ ２ 蛋白阳性２０ 例（３２－２６ ％） ，其中鳞癌１５ 例，腺癌５ 例；ｐ５３ 蛋白阳性４９ 例（７９－０３ ％ ） ，其中鳞癌３４ 例，腺癌１５ 例。两者比较差异非常显著（ Ｐ＜０－０１） 。⑵ｂｃｌ－２ 和ｐ５３ 的表达强度与肺癌的分化程度密切，但两者之间的表达相反；４８ 例随访患者发现ｐ５３ 表达阳性率与生存期有关，而与ｂｃｌ－ ２ 表达则关系不密切。说明对非小细胞肺癌原位检测ｂｃｌ－ ２、ｐ５３ 蛋白有助肺癌的诊断。
In order to study the relationship between bcl-2 and p53 protein expression and their clinicopathological significance in the non-small-cell lung carcinoma,the lung carcinoma tissues from 62 patients were detected with immunohistochemical S-P method.20 cases (32.26%) were positive of bcl-2 protein,and 15 cases of them were squamous-cell carcinomas,5 cases of them were adenocarcinoma;49 cases (79.03%) were positive of p53 protein,and 34 cases of them were squamous-cell carcinoma,15 cases of them were adenocarcinoma.Statistically significant difference existed after comparing(P<0 01).The results showed that there was a close correlation between expression intensity of bcl-2,p53 and differentiation degree of lung carcinoma.The expressions of both bcl-2 and p53 were negatively related.The survival time of the patients was associated with positive rate of p53 expression,but it has not a close associated with bcl-2 expression,suggesting the in situ detection of bcl-2,p53 proteins in non-small-cell lung carcinomas might be helpful for the diagnosis of lung carcinoma and has an important prognostic significance.
出处
《中国医师杂志》
CAS
2000年第1期12-14,共3页
Journal of Chinese Physician
关键词
BCL-2
P53
非小细胞肺癌
免疫组化法
诊断
Oncogenic proteins,bcl-2,p53
Non-small-cell lung carcinoma
Immunohistochemical method
Diagnosis
