摘要
目的:为了探讨血管内皮生长因子(VEGF)的检测在冠心病患者中的意义。方法:应用双抗夹心ELISA法检测了55例冠心病(CHD)患者和34例正常对照者的血清VEGF水平。结果:CHD患者血清VEGF水平(498.98±304.50)pg/ml明显高于正常对照组(121.49±30.29)pg/ml,P<0.01;其中急性心肌梗塞(AMI)患者组血清VEGF水平(809.21±191.16)pg/ml明显高于心绞痛患者组(292.14±148.56)pg/ml,P<0.01,而且两者均高于正常对照组。结论:提示VEGF可能是反映心肌缺血的敏感指标。
Objective: To investigate the role of serum vascular endothelial growth factor (VEGF) in the pathogenesis of coronary heart disease(CHD). Methods: Serum VEGF levels of 55 cases of CHD and 34 cases of normal controls were determined by enzyme linked immunosorbent assay (ELISA). Results: Serum VEGF levels of CHD patients (498.98±304.50) pg/ml were much higher than that of normal controls(121.49± 30.29) pg/ml, P <0.01.The serum VEGF levels of acute myocardial infarction(AMI)patients (809.21±191.16) pg/ml were higher than that of angina patients(292.14±148.56) pg/ml, P <0.01,and the serum VEGF levels in both groups patients were higher than that in normal controls. Conclusion: The results suggest that the serum VEGF level might be a sensitive index to reflect myocardial ischemia.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2000年第2期108-109,共2页
Chinese Journal of Immunology
基金
广东省卫生厅科研基金!批准文号A1998189
关键词
冠心病
VEGF
诊断
ELISA
Vascular endothelial growth factor Acute myocardial ischemia Myocardial infarction Angina
