摘要
目的:探讨肾综合征出血热(HFRS)发病机理中,自由基(OFR)对T淋巴细胞亚群的影响。方法:对54例HFRS患者进行血清SOD、MDA、T细胞亚群进行动态观察。结果:显示SOD含量在发热期明显低于正常对照组,MDA含量在发热期明显高于正常对照组,CD4+细胞在发热期明显降低,CD8+细胞在发热期明显升高,其变化在少尿期最重,并且发现MDA和T细胞亚群变化有一定的相关性,即MDA与CD8+细胞百分比是正相关,与CD4+/CD8+负相关。结论:HFRS患者免疫功能紊乱现象与OFR反应有关。
Objective:To study the correlation between the effects of oxygen free radicals (OFR) with T cell subsets on pathogenesis of hemorrhagic fever with syndrome(HFRS).Methods:Serum levels of SOD and MDA.T cell subsets in 54 patients with HFRS were sequentially investigate and correlation. Results:The level of serum SOD in febrile phase was lower than that of normal control.The level of serum MDA in febrile phase was higher than that of normal group;the sum of CD4 + cell in febrile phase was signficantly lower than that normal group,CD8 + cell was significantly higher than that of control group,and its changes must severe in oliguric phase.The resuts also showed that there was sum correlation existed between MDA and T cell subsets.Conclusion:These findings demonstrated that irregulating immunity of HFRS patients was correlation with OFR.
出处
《中国免疫学杂志》
CSCD
北大核心
2000年第2期106-107,共2页
Chinese Journal of Immunology
关键词
肾综合征出血热
SOD
丙二醛
T细胞亚群
Hemorrhagic fever with syndrome(HFRS) Oxygen free radicals(OFR) Superoxidedismu tase(SOD) Malendiadeghyde(MDA) T cell subsets
